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´Ù¿î·Îµå : Áø¼¼³ë»çÀ̵带 ÀÌ¿ëÇÑ ³úÀÎÁö±â´É Çâ»ó¿¡ ´ëÇÑ ¿¬±¸_ÇÑÁøÈñ ±³¼ö.pdf(218 Kb)
 

Áø¼¼³ë»çÀ̵带 ÀÌ¿ëÇÑ ³úÀÎÁö±â´É Çâ»ó¿¡ ´ëÇÑ ¿¬±¸

 

                                                                                                            

Çѱ¹°úÇбâ¼ú¿ø ÇÑÁøÈñ ±³¼ö

 

 1. °³¿ä

 Àλï(ginseng)Àº µ¿¾ç±Ç ±¹°¡¿¡¼­ ¼öõ ³â ÀüºÎÅÍ ¹Î°£ ÀǾàÀ¸·Î »ç¿ëµÇ¾î ¿À°í ÀÖ´Ù. ÀλïÀÇ ÀÇÇÐÀû »ç¿ëÀº ±â¿øÀü 33³âÀÇ °í´ë Áß±¹ ¹®Çå ±â·Ï¿¡¼­µµ ¾ð±ÞÀÌ µÇ¾îÀÖÀ¸¸ç, Çѱ¹¿¡¼­ ÀÚ¶ó´Â Panax ginseng, Áß±¹¿¡¼­ ÀÚ¶ó´Â Panax notoginseng, ¹Ì±¹ ´ë·ú¿¡¼­ ¹ß°ßµÇ´Â Panx quinquefolium µîÀÇ ´Ù¾çÇÑ Àλï Á¾ÀÌ Á¸ÀçÇÏ°í ÀÖ´Ù. ÀλïÀÌ °¡Áø ¿©·¯ ÀÇÇÐÀû È¿´É °¡¿îµ¥, ÇнÀ È¿°ú¿Í ±â¾ï·Â Çâ»ó¿¡ °¡Áö°í ÀÖ´Â È¿´ÉÀÌ ÁÖ¸ñµÇ¾úÀ¸¸ç ÃÖ±Ù¿¡´Â ¿©·¯ ½ÇÇèÀû, ÀÓ»óÀû ½Ãµµ¸¦ ÅëÇÏ¿© ÀλïÀÌ °¡Áö´Â ±â¾ï·Â Çâ»ó È¿°ú¿¡ ´ëÇÑ ¿¬±¸°¡ ÁøÇàµÇ¾î ¿À°í ÀÖ´Ù. ¾Õ¼± ¿¬±¸¸¦ ÅëÇÏ¿© ±â¾ï·Â Çâ»ó È¿°ú¿¡ ±â¿©ÇÏ´Â Àλï ÁÖ ¼ººÐÀ¸·Î Áø¼¼³ë»çÀ̵å(ginsenoside)¶ó´Â È­ÇÕ¹°ÀÌ ¿¬±¸ÀÇ ÁÖ ´ë»óÀ¸·Î ÁÖ¸ñ¹Þ¾Ò´Ù. Áø¼¼³ë»çÀ̵å´Â ÀλïÀÇ ÁÖ¿ä ¾à¸®È¿°ú¸¦ ³ªÅ¸³»´Â Dammarane-type Triterpene SaponinsÀÇ Æ¯Â¡À» °¡Áö´Â õ¿¬È­ÇÕ¹°·Î 180Á¾ ÀÌ»óÀÇ Áø¼¼³ë»çÀ̵尡 ¾Ë·ÁÁ® ÀÖ´Ù (±×¸² 1). Áø¼¼³ë»çÀ̵å´Â Àλ£ ÇÔÀ¯µÇ¾î ÀÖ´Â ¾ç¿¡ µû¶ó ¸ÞÀÌÀú, ¸¶ÀÌ³Ê Áø¼¼³ë»çÀ̵å·Î ³ª´µ´Âµ¥, ÀÌ Áß ¸ÞÀÌÀú Áø¼¼³ë»çÀ̵忡 ÇØ´çµÇ´Â Rg1, Rb1 µîÀÇ Áø¼¼³ë»çÀ̵å´Â ±â¾ï·Â Çâ»óÀÇ È¿°ú°¡ ÀÖÀ½ÀÌ ½ÇÇèÀûÀ¸·Î ÀÔÁõµÇ¾ú´Ù (Mook-Jung et al. 2001). 


 ³ëÈ­ (Senescence), ¾ËÃ÷ÇÏÀÌ¸Ó (Alzheimer's disease) µîÀÇ ¿øÀÎÀ¸·Î ³ªÅ¸³ª´Â Ä¡¸Å´Â ½Å°æ ÅðÇ༺ ³úÁúȯÀÇ ÀÏÁ¾À¸·Î Çö´ë »çȸÀÇ ÁÖ¿ä Áúȯ Áß Çϳª·Î ºÐ·ùµÉ ¸¸Å­ Áß¿äÇÑ »çȸÀû ¹®Á¦·Î °í·ÁµÇ°í ÀÖ´Ù. Ä¡¸ÅÀÇ ¿©·¯ Áõ»ó Áß °¡Àå Áß¿äÇÑ °ÍÀº ±â¾ï·Â °¨Åð ¹× ÀÎÁö ±â´É ÀúÇÏÀÌ´Ù. Ä¡¸ÅÀÇ ¿øÀΰú Ä¡·á ¹æ¹ý¿¡ ´ëÇÑ ¿¬±¸°¡ È°¹ßÈ÷ ÁøÇà ÁßÀÌÁö¸¸, ¾ÆÁ÷±îÁö ¸íȮȯ ¿øÀÎÀÇ ±Ô¸í°ú È®½ÇÇÑ Ä¡·á ¹æ¹ýÀÌ ¹àÇôÁöÁö ¾ÊÀº »óȲÀÌ´Ù.

 

 

±×¸² 1 Áø¼¼³ë»çÀ̵åÀÇ Á¾·ù

 

Áø¼¼³ë»çÀ̵å´Â ÀÎ»ï ³» ÇÔÀ¯·®¿¡ µû¶ó ¸ÞÀÌÀú/¸¶ÀÌ³Ê Áø¼¼³ë»çÀ̵å·Î ³ª´¶´Ù. ÇÔÀ¯·®ÀÌ 95% ÀÌ»óÀÎ Rb1, Rd, Rg1 µîÀÌ ¸ÞÀÌÀú Áø¼¼³ë»çÀ̵å·Î ºÐ·ùµÇ¸ç ½ÇÁ¦ Àλ£¼­´Â ¸¶ÀÌ³Ê Áø¼¼³ë»çÀ̵å·ÎºÎÅÍ ¸ÞÀÌ³Ê Áø¼¼³ë»çÀ̵å·Î »ýÇÕ¼º µÇ¾î ÀúÀåµÈ´Ù.

 

 ±× Áß ÇнÀ°ú ±â¾ï¿¡ ´ëÇÑ Áø¼¼³ë»çÀ̵åÀÇ ¾à¸® È¿°ú¸¦ ¿¬±¸ÇÏ´Â ¿©·¯ ¿¬±¸ÆÀ¿¡¼­´Â ¸î¸î Á¾·ùÀÇ Áø¼¼³ë»çÀ̵尡 Ä¡¸Å ÁúȯÀÇ ÁøÇàÀ» ´ÊÃß°í Ä¡¸Å¿¡ ÀÇÇÑ ÀÎÁö ±â´É ÀúÇÏ Çö»óÀ» ȸº¹½Ãų ¼ö ÀÖ´Ù´Â ¿¬±¸ °á°ú¸¦ ¹ßÇ¥ÇÏ°í ÀÖ´Ù. ÇØ´ç ¿¬±¸ °á°úµéÀº Áø¼¼³ë»çÀ̵尡 Ä¡¸Å ÁøÇà ¾ïÁ¦¿¡ °®´Â »ý¸®ÇÐÀû È¿°ú, Ä¡¸Å ¸ðµ¨ ½ÇÇ赿¹°¿¡¼­ º¸ÀÌ´Â ÀÎÁö ±â´É ȸº¹ È¿°úµéÀ» º¸¿©ÁÖ°í ÀÖ´Ù. µû¶ó¼­ º» º¸°í¼­¿¡¼­´Â ¿©·¯ ½Å°æ ÅðÇ༺ Áúȯ ¸ðµ¨¿¡¼­ ³ªÅ¸³ª´Â Áø¼¼³ë»çÀ̵åÀÇ Ä¡·á È¿°ú¿¡ ´ëÇÑ ½ÇÇèÀû °á°úµéÀ» Áß½ÉÀ¸·Î Áø¼¼³ë»çÀ̵åÀÇ ¾à¸® È¿°ú ±Ô¸í¿¡ ´ëÇÑ ¿¬±¸ µ¿Çâ¿¡ ´ëÇØ °íÂûÇØ º¸°íÀÚ ÇÑ´Ù.

 

 2. Áø¼¼³ë»çÀ̵尡 Ä¡¸Å ¸ðµ¨¿¡¼­ º¸ÀÌ´Â ¾à¸® È¿°ú

 Áø¼¼³ë»çÀ̵尡 Ä¡¸Å Ä¡·á¿¡ º¸ÀÌ´Â È¿°ú¸¦ ¿¬±¸Çϱâ À§ÇÏ¿© ÃÖ±ÙÀÇ ¿¬±¸¿¡¼­´Â Ä¡¸Å ȯÀÚ¿¡¼­ ³ªÅ¸³ª´Â »ý¸®ÇÐÀû Çö»óÀ» ¸ð¹æÇÒ ¼ö ÀÖ´Â ¿©·¯ Ä¡¸Å ¸ðµ¨ ½Ã½ºÅÛ (¼¼Æ÷ÁÖ ¶Ç´Â ½ÇÇ赿¹°)À» È°¿ëÇÏ¿´´Ù. ÀÌ·¯ÇÑ ¸ðµ¨ ½Ã½ºÅÛµéÀº ´ëºÎºÐ ¾Æ¹Ð·ÎÀ̵å(Amyloid) ´Ü¹éÁúÀÇ ÇöóÅ© Çü¼ºÀ» À¯µµÇÏ°í Àִµ¥, ¾Æ¹Ð·ÎÀ̵å ÇöóÅ© Çü¼ºÀº ´ëºÎºÐÀÇ Ä¡¸Å ȯÀÚµéÀÇ ³ú Á¶Á÷¿¡¼­ ¹ß°ßµÇ¸ç ½Å°æ ¼¼Æ÷ÀÇ ¼Õ»óÀ» ÀÏÀ¸ÄÑ Ä¡¸ÅÀÇ ÁÖ¿ä Áõ»óµéÀ» ÀÏÀ¸Å°´Â ÁÖ ¿øÀÎÀ¸·Î Áö¸ñµÇ°í ÀÖ´Ù. ÇÑ ¿¬±¸¿¡¼­´Â ³­¼Ò ÀûÃâ(Ovariectomized) Áã¿¡ D-galactose¸¦ ÁÖÀÔÇÏ¿© ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁúÀÇ ¹ßÇöÀÌ Áõ°¡ÇÑ Ä¡¸Å ¸ðµ¨ Á㸦 »ý»êÇÏ°í, ÀÌ ¸ðµ¨¿¡ Áø¼¼³ë»çÀ̵å Rg1À» 6ÁÖ °£ Åõ¿©ÇÏ¿© Ä¡¸Å Áõ»ó¿¡ ¹ÌÄ¡´Â ¿µÇâÀ» °üÂûÇÏ¿´´Ù.

±× °á°ú, Áø¼¼³ë»çÀ̵å Rg1À» Åõ¿©ÇÑ Áã¿¡¼­ ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁúÀÇ ¾çÀÌ °¨¼ÒÇÏ°í ¼Õ»óµÇ¾ú´ø °ø°£

±â¾ï ´É·ÂÀÌ È¸º¹µÇ´Â °ÍÀ» °üÂûÇÒ ¼ö ÀÖ¾ú´Ù (±×¸² 2,3 X. Zhang et al. 2012).

 

±×¸² 2 Ä¡¸Å ¸ðµ¨¿¡¼­ Áø¼¼³ë»çÀ̵å Rg1¿¡ ÀÇÇÑ °ø°£ ±â¾ï ȸº¹.

 

°ø°£ ±â¾ï¿¡ ´ëÇÑ ½ÇÇèÀû °ËÁõ ¹æ¹ýÀÎ Morris water maze ½ÇÇè¿¡¼­ Rg1À» Åõ¿©ÇÑ ±×·ì(O+D+L/+M/+H)ÀÌ Rg1À» Åõ¿©ÇÏÁö ¾ÊÀº Ä¡¸Å ¸ðµ¨ ±×·ì(O+D)°ú ºñ±³ÇÏ¿´À» ¶§, ´ëÁ¶±º(CT)¿¡ ±ÙÁ¢ÇÑ °ø°£ ±â¾ï ´É·ÂÀ» º¸¿©ÁÖ°í ÀÖ´Ù. (X. Zhang et al.2012)

±×¸² 3 Ä¡¸Å ¸ðµ¨¿¡¼­ Áø¼¼³ë»çÀ̵å Rg1¿¡ ÀÇÇÑ ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁú Çü¼º ¾ïÁ¦ Rg1À»

Åõ¿©ÇÑ ±×·ìÀÌ Rg1À» Åõ¿©ÇÏÁö ¾ÊÀº Ä¡¸Å ¸ðµ¨ ±×·ì°ú ºñ±³ÇÏ¿´À» ¶§

´õ ³·Àº ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁú ¼öÁØÀ» º¸ÀÌ°í ÀÖ´Ù. (X. Zhang et al. 2012)

 

 °°Àº ¿¬±¸¿¡¼­ Áø¼¼³ë»çÀ̵å Rg1ÀÇ Åõ¿©´Â ¾Æ¹Ð·ÎÀ̵å Àü±¸Ã¼¸¦ ºÐÇØÇÏ¿© ¾Æ¹Ð·ÎÀ̵å ÇöóÅ© Çü¼ºÀ» ÃËÁø½Ãų ¼ö ÀÖ´Â BACE 1 È¿¼ÒÀÇ ¹ßÇöÀ» °¨¼Ò½ÃÅ°´Â °ÍÀ» È®ÀÎÇÏ¿´´Ù. ÀÌ¿Í °ü·ÃÇÏ¿© 2012³â Li-min Chen ÆÀ¿¡¼­´Â amyloidogenesisÀÇ in vitro ¸ðµ¨·Î »ç¿ëµÇ´Â N2a-APP695 ¼¼Æ÷ÁÖ¿¡ Rg1À» ó¸®ÇÏ¿´À» ¶§, BACE 1 ÇÁ·Î¸ðÅÍ¿¡ °áÇÕÇÏ¿© BACE 1 À¯ÀüÀÚ Àü»ç¸¦ ¾ïÁ¦½ÃÅ°´Â PPAR¥ã°¡ ¼¼Æ÷Áú·ÎºÎÅÍ ÇÙÀ¸·Î À̵¿ÇÏ¿© BACE 1ÀÇ À¯ÀüÀÚ ¹ßÇö ¼öÁØÀ» °¨¼Ò½ÃÅ°´Â °ÍÀ» °üÂûÇÏ¿´´Ù. °á°úÀûÀ¸·Î ÀÌ´Â ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁúÀÇ ÇöóÅ© Çü¼ºÀ» °¨¼Ò½ÃÄÑ Áø¼¼³ë»çÀ̵å Rg1¿¡ ÀÇÇÏ¿© ¾ËÃ÷ÇÏÀÌ¸Ó º´ÀÇ Áõ»óÀ» ¿ÏÈ­ÇÒ ¼ö ÀÖ´Ù´Â ±Ù°Å°¡ µÈ´Ù.


 ¶ÇÇÑ, ´Ù¸¥ ¿¬±¸ÆÀ¿¡¼­´Â ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁúÀ» ó¸®ÇÑ PC12 ¼¼Æ÷ÁÖ¿¡ Áø¼¼³ë»çÀ̵å Rg1À» ó¸®ÇÏ¿´À» ¶§, Á¥»êÅ»¼ö¼ÒÈ¿¼Ò(LDH), ÀÏ»êÈ­Áú¼Ò(NO), È°¼º»ê¼Ò(ROS) ¹ß»ý ¹× ¼¼Æ÷ ³» Ä®½· ³óµµ Áõ°¡ µîÀÇ ¼¼Æ÷ ¼Õ»ó ½ÅÈ£°¡ °¨¼ÒÇÏ´Â °ÍÀ» °üÂûÇÏ¿´´Ù. À̸¦ ÅëÇÏ¿© Áø¼¼³ë»çÀ̵å Rg1ÀÌ ¾Æ¹Ð·ÎÀ̵å ÇöóÅ©ÀÇ Çü¼ºÀ» ¸·´Â °Í¿¡¸¸ °ü¿©ÇÏ´Â °ÍÀÌ ¾Æ´Ï¶ó ¾Æ¹Ð·ÎÀ̵å ÇöóÅ©¿¡ ÀÇÇÑ ¼¼Æ÷ ¼Õ»óÀ» ¿ÏÈ­ÇÏ´Â µ¥¿¡µµ ¿ªÇÒÀ» ÇÒ ¼ö ÀÖ´Ù´Â »ç½ÇÀÌ ÀÔÁõµÇ¾ú´Ù (Yue-hua Wang et al. 2009).
 Áø¼¼³ë»çÀ̵å Rg1ÀÌ ¾Æ¹Ð·ÎÀ̵å ÇöóÅ©ÀÇ Çü¼º°ú ÀÌ¿¡ µû¸¥ ¼¼Æ÷ ¼Õ»óÀ» ¸·À» ¼ö ÀÖ´Â ¸ÞÄ¿´ÏÁò¿¡ °üÇÑ ¿¬±¸´Â 2012³â Chun shi ÆÀ¿¡ ÀÇÇÏ¿© º¸°íµÇ¾ú´Ù. Áø¼¼³ë»çÀ̵å Rg1Àº È£¸£¸ó À¯»ç¹°ÁúÀº ÇÇÅä¿¡½ºÆ®·ÎÁ¨ (Phytoestr -ogen)À¸·Î ¾Ë·ÁÁ® ÀÖ¾î ¿¡½ºÆ®·Î°Õ ¼ö¿ëü ½ÅÈ£Àü´Þ°æ·Î¸¦ È°¼ºÈ­ ½Ãų ¼ö ÀÖÀ» °ÍÀ¸·Î ÃßÃøµÇ¾ú´Ù. ÇØ´ç ¿¬±¸ÆÀ¿¡¼­´Â Áø¼¼³ë»çÀ̵å Rg1ÀÇ Ã³¸®°¡ ¿¡½ºÆ®·Î°Õ ¼ö¿ëü¸¦ ÀλêÈ­½ÃÅ°´Â °ÍÀ» È®ÀÎÇÏ¿´À¸¸ç ¿¡½ºÆ®·Î°Õ ½ÅÈ£Àü´Þ°æ·Î »ó¿¡ ÀÖ´Â PKC, ERK/MAPK, PI3K/AktµîÀÇ ¾ïÁ¦Á¦¸¦ Åõ¿©ÇÏ¿© Áø¼¼³ë»çÀ̵å Rg1¿¡ ÀÇÇÑ È¿°ú°¡ »ç¶óÁö´Â °ÍÀ» °üÂûÇÔÀ¸·Î½á Áø¼¼³ë»çÀ̵å Rg1ÀÇ È¿°ú°¡ ¿¡½ºÆ®·Î°Õ ½ÅÈ£Àü´Þ°æ·Î¸¦ ÅëÇÏ¿© ³ªÅ¸³­´Ù´Â °ÍÀ» ¹ßÇ¥ÇÏ¿´´Ù.


 ÇÑÆí, SAMP8 (Senescence accelerated mouse prone 8) ³ëÈ­ »ýÁã ¸ðµ¨À» ÀÌ¿ëÇÑ ¿¬±¸ÆÀ¿¡¼­´Â 3°³¿ù°£ÀÇ Áø¼¼³ë»çÀ̵å Rg1ÀÇ Åõ¿©¸¦ ÅëÇØ ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁúÀÇ °¨¼Ò, ±â¾ï·Â ȸº¹°ú ´õºÒ¾î PKA/CREB ½ÅÈ£Àü´Þ°æ·ÎÀÇ È°¼ºÈ­, BDNF (Brain derived neurotrophic factor)ÀÇ Áõ°¡ µîÀ» °üÂûÇÏ¿´´Ù (Yan-Qing Shi et al. 2010). PKA, CREB, BDNF´Â ¿©·¯ µ¿¹°¿¡¼­ Àå±â ±â¾ï Çü¼º¿¡ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù´Â °ÍÀÌ ¹àÇôÁø ºÐÀÚµé·Î À§ÀÇ ¿¬±¸ °á°ú¸¦ ÅëÇØ Áø¼¼³ë»çÀ̵å Rg1ÀÌ Ä¡¸Å ¸ðµ¨¿¡¼­ ±â¾ï·Â ȸº¹ È¿°ú¸¦ ÀÏÀ¸Å³ ¼ö ÀÖ´Ù´Â °ÍÀ» ´õ¿í ±â´ëÇØ º¼ ¼ö ÀÖ´Ù. ÀÌ·¯ÇÑ PKA/CREB ½ÅÈ£Àü´Þ°æ·ÎÀÇ È°¼º Áõ°¡´Â ¾Æ¹Ð·ÎÀ̵å Àü±¸Ã¼ °ú¹ßÇöÀ» ÀÌ¿ëÇÑ Fang ÆÀÀÇ ¿¬±¸¿¡¼­µµ ¹ßÇ¥µÇ¾ú´Ù (Fang et al. 2012).
 ¶ÇÇÑ, Áø¼¼³ë»çÀ̵å Rg1Àº ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁú¿¡ ÀÇÇÑ ¹ÌÅäÄܵ帮¾ÆÀÇ ¿ª±â´É ¹× °ú»êÈ­¼ö¼Ò ³ëÃâ¿¡ ÀÇÇÑ ¼¼Æ÷ ¼Õ»ó ¿ÏÈ­¸¦ ÅëÇØ ¼¼Æ÷ »ç¸êÀ» ¾ïÁ¦ÇÒ ¼ö ÀÖ´Â °ÍÀ¸·Î ¹àÇôÁ³´Ù. ±× ¿Ü¿¡µµ Áø¼¼³ë»çÀ̵å Rg1ÀÌ ³úÀÇ Çظ¶(Hippocampus) ¿µ¿ª¿¡¼­ ½Å°æÀü±¸¼¼Æ÷ÀÇ Áõ½Ä°ú ºÐÈ­¸¦ ÃËÁø½Ãų ¼ö ÀÖ´Ù´Â ¿¬±¸ °á°úµéÀÌ ¹ß°ßµÊ¿¡ µû¶ó Áø¼¼³ë»çÀ̵å Rg1¿¡ ÀÇÇÑ ½Å°æ ÅðÇ༺ Áúȯ Ä¡·á È¿°ú¸¦ ±â´ëÄÉ ÇÑ´Ù (Cheng et al. 2005, Huang et al. 2012, Liu et al. 2011).


 Áø¼¼³ë»çÀ̵å Rg1 ¿Ü¿¡ ´Ù¸¥ Áø¼¼³ë»çÀ̵åÀÇ °æ¿ì¿¡µµ Ä¡¸Å Ä¡·á È¿°ú¸¦ º¸Àδٴ ¿¬±¸ °á°ú°¡ ÀÖ´Ù. ¾Æ¹Ð·ÎÀ̵å ÇöóÅ© Çü¼º ¿Ü¿¡ Ÿ¿ì (tau) ´Ü¹éÁúÀÇ °úÀλêÈ­µµ ¾ËÃ÷ÇÏÀÌ¸Ó º´ÀÇ ¿øÀÎÀ¸·Î Áö¸ñµÈ´Ù. 2011³â Ling Li ÆÀ¿¡¼­´Â ´Ü¹éÁú Å»ÀλêÈ­È¿¼ÒÀÇ ¾ïÁ¦Á¦ÀÎ okacaic »êÀ» »ç¿ëÇÏ¿© Ÿ¿ì ´Ü¹éÁúÀÇ °úÀλêÈ­¸¦ À¯µµÇÑ ¸ðµ¨¿¡ Áø¼¼³ë»çÀ̵å Rd¸¦ ó¸®ÇÑ °á°ú, ´Ü¹éÁú Å»ÀλêÈ­È¿¼ÒÀÎ PP-2AÀÇ È°¼ºÀ» Áõ°¡½ÃÄÑ Å¸¿ì ´Ü¹éÁúÀÇ °úÀλêÈ­¸¦ ¸·°í ÀÌ·Î ÀÎÇÑ ½Å°æ ¼¼Æ÷ÀÇ µ¶¼ºÀ» °¨¼Ò½ÃÅ°´Â °ÍÀ» °üÂûÇÏ¿´´Ù. 
 ¶ÇÇÑ, Áø¼¼³ë»çÀ̵å Rg2´Â °ú·®ÀÇ ±Û·çŽ»ê¿¡ ÀÇÇÑ ½Å°æ¼¼Æ÷ µ¶¼ºÀ» ¿ÏÈ­ÇÏ´Â ¿ªÇÒÀÌ ¹àÇôÁ³À¸¸ç Áø¼¼³ë»çÀ̵å Rb1, Rg3ÀÇ °æ¿ì¿¡µµ ¾Æ¹Ð·ÎÀ̵å ÇöóÅ©·ÎºÎÅÍ ½Å°æ¼¼Æ÷¸¦ º¸È£ ¶Ç´Â ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁú ¼öÁØÀ» °¨¼Ò½ÃÅ°´Â ¹æ½ÄÀ» ÅëÇØ Ä¡¸Å Áõ»óÀ» ¿ÏÈ­ÇÒ ¼ö ÀÖ´Ù´Â º¸°íµéÀÌ ÀÖ´Ù (Li et al. 2007, Xiaxie et al. 2010, Yang et al. 2009). À§ÀÇ ¿©·¯ ¿¬±¸ °á°úµéÀº ´Ù¾çÇÑ Á¾·ùÀÇ Áø¼¼³ë»çÀ̵尡 ½Å°æ ÅðÇ༺ ÁúȯÀÇ ÇϳªÀÎ Ä¡¸Å Ä¡·á¿¡ È¿°úÀûÀÎ ¾à¹°·Î¼­ »ç¿ëµÉ ¼ö ÀÖÀ½À» ½Ã»çÇÏ°í ÀÖ´Ù.

 

 3. °íÂû 
 Áø¼¼³ë»çÀ̵å´Â Ä¡¸ÅÀÇ ÁÖ ¿øÀÎÀÎ ¾Æ¹Ð·ÎÀÌµå ´Ü¹éÁú ÇöóÅ©ÀÇ Çü¼ºÀ» ¾ïÁ¦ÇÏ°í ÀÌ¿¡ µû¸¥ ½Å°æ ¼¼Æ÷ ¼Õ»óÀ» ¸·À¸¸ç ±â¾ï Çü¼º¿¡ °ü¿©ÇÏ´Â ¼¼Æ÷ ³» ºÐÀÚµéÀ» È°¼ºÈ­ÇÏ¿© Ä¡¸Å Ä¡·á ¾à¹°·Î È°¿ëµÉ ¼ö ÀÖ´Â ÀáÀç·ÂÀ» °¡Áö°í ÀÖ´Ù. ¶ÇÇÑ, ´Ù¸¥ ½Å°æ ÅðÇ༺ Áúȯ Áß ÇϳªÀÎ ÆÄŲ½¼¾¾º´ (Parkinson's disease) ¸ðµ¨ ½Ã½ºÅÛ¿¡¼­µµ Áø¼¼³ë»çÀ̵åÀÇ Åõ¿©°¡ µµÆĹΠ½Å°æ¼¼Æ÷ÀÇ »ç¸êÀ» ¸·À½À¸·Î½á µµÆĹΠºÎÁ·¿¡ ÀÇÇÑ ÆÄŲ½¼¾¾º´¿¡ Ä¡·á È¿°ú¸¦ º¸ÀÏ ¼ö ÀÖ´Ù´Â ¿¬±¸ °á°úµµ º¸°íµÇ°í ÀÖ´Ù (Xu et al. 2009, Chen et al. 2005). Çö´ë »çȸ¿¡¼­ Ä¡¸Å´Â ´Ù¾çÇÑ ¹ßº´ ¿øÀÎ ¹× Ä¡·á ¾à¹°ÀÇ ºÎÀç µîÀ¸·Î ÀÎÇÏ¿© È¿°úÀûÀÎ Ä¡·á¿¡ ³­Ç×À» °Þ°í ÀÖ´Ù. Ä¡¸Å¸¦ Æ÷ÇÔÇÑ ¿©·¯ ½Å°æ ÅðÇ༺ Áúȯ¿¡¼­ °®´Â Áø¼¼³ë»çÀ̵åÀÇ ¾à¸® È¿°ú¿¡ °üÇÑ ¿¬±¸ °á°úµéÀº Áø¼¼³ë»çÀ̵带 ÀÌ¿ëÇÑ Ä¡¸Å Ä¡·á¿¡ Å« µµ¿òÀÌ µÉ °ÍÀ¸·Î ±â´ëµÇ°í ÀÖ´Ù. ¾ÕÀ¸·Î´Â Áø¼¼³ë»çÀ̵尡 º¸ÀÌ´Â Ä¡·á È¿°ú¿¡ ´ëÇÑ ½ÇÇèÀû ¿¬±¸¿Í ÇÔ²² Ä¡¸Å Ä¡·á¿¡ Á÷Á¢ÀûÀ¸·Î È°¿ë °¡´ÉÇÑ ÀÓ»óÀû ¿¬±¸ °á°úµéÀÌ ´õÇØÁ® Áø¼¼³ë»çÀ̵带 Á÷Á¢ÀûÀ¸·Î Ä¡¸Å Ä¡·á ¾à¹°·Î¼­ È°¿ëÇÒ ¼ö ÀÖµµ·Ï ÇÏ´Â ¿¬±¸µéÀÌ ÁøÇàµÉ °ÍÀ¸·Î Àü¸ÁµÈ´Ù.

 

 Âü°í¹®Çå
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    Alzheimer Res. 2012 3: 388–95.
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   Ginsenoside Rg1 attenuates ¥â-amyloid generation via suppressing PPAR¥ã-regulated BACE1 activity in

    N2a-APP695 cells. European Journal of Pharmacology 2012 675:15–21
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    against Ab-induced cytotoxicity in PC12 cells. Journal of Asian Natural Products Research 2009

    11:604-612
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    PI3K/Akt. Biochimica et Biophysica Acta 2012 1820:453–460
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Total:118 page:(8/5)
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